

Severe IRIS may threaten a patient’s functional status or cause permanent disability or death. Mild IRIS resolves over time in most patients, and symptomatic treatment is often sufficient.

This early complication is seen most often within the first 8 weeks of therapy in patients with advanced HIV disease. The NYSDOH AI is publishing this guideline at a critical time: 1) Initiation of ART is now recommended for all patients diagnosed with HIV 2) Identifying and linking patients with HIV infection to care and treatment that achieves optimal virologic suppression are crucial to the success of New York State’s Ending the Epidemic initiative and 3) The ability of primary care providers and other clinicians in New York State to manage IRIS is key to the successful treatment of patients with HIV.Īlthough ART dramatically reduces HIV-associated mortality and improves patient outcomes, initiation of or a change in ART introduces the potential for IRIS.

This guideline was developed by the New York State Department of Health (NYSDOH) AIDS Institute (AI) for primary care providers and other practitioners who manage immune reconstitution inflammatory syndrome (IRIS) in patients with HIV. Gonzalez, MDĬommittee: Medical Care Criteria Committee Purpose Radix, MD, MPH, PhD, FACP, AAHIVS Rona M. Original publication: June 2017 Steven M.
